Proper Name: d-alpha tocopheryl succinate

Common Name: Vitamin E

Evidence of Efficacy: statement to the effect of Vitamin E deficiency or imbalance plays a role in the symptoms of mood disorders. Observational and experimental studies have shown an association between vitamin D and anxiety¹ , depression², premenstrual syndrome^3,4,5,6,7, and schizophrenia⁸.

References: 

1. Heseker H, Kubler W, Pudel V, Westenhoffer J. Psychological disorders as early symptoms of a mild-moderate vitamin deficiency. Ann N Y Acad Sci 669:352-7, 1992.
2. Maes M, De Vos N, Pioli R, Demedts P, Wauters A, Neels H, Christophe A.; Lower serum vitamin E concentrations in major depression. Another marker of lowered antioxidant defenses in that illness. J Affect Disord. Jun;58(3):241-6, 2000.
3. Chuong CJ, Dawson EB, Smith ER. Vitamin E levels in premenstrual syndrome. Am J Obstet Gynecol 163 (5 Pt 1):1591-5, 1990.
4. Mira M, Stewart PM, Abraham SF. Vitamin and trace element status in premenstrual syndrome. Am J Cin Nutr 47(4):636-41, 1988.
5. London RS, Murphy L, Kitlowski KE, Reynolds MA. Efficacy of alpha-tocopherol in the treatment of the premenstrual syndrome. J Reprod Med 32(6):400-4, 1987.
6. Londong RS, Sundaram GS, Murphy L, Goldstein PJ. The effect of alpha-tocopherol on premenstrual symptomatology: A double-blind study. J Am Coll Nutr 2(2):115-22, 1983.
7. Londong RS, et al., The effect of alpha-tocopherol on premenstrual symptomatology: A double-blind study. II. Endocrine correlates.  J Am Coll Nutr 3:351, 1984.
8. Arvindakshan M, Ghate M, Ranjekar PK, Evans DR, Mahadik SP.; Supplementation with a combination of omega-3 fatty acids and antioxidants (vitamins E and C) improves the outcome of schizophrenia. Schizophr Res. Aug 1;62(3):195-204, 2003.