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Proper Name:
Folic Acid
Common Name:
Vitamin B9
Evidence of Efficacy: statement to the effect of
Vitamin B9 deficiency or imbalance plays a role in the
symptoms of mood disorders. Observational and
experimental studies have shown an association between
vitamin B9 and bipolar disorder1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,
depression18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31,3 2,33 ,34 ,35, 36, 37,3 8,39 ,40, 41,4 2,43 ,44, 45, 46, 47, 48, 49,5 0,5 1,5 2,53, 54,5 5,56 ,57, 58,5 9,
and schizophrenia60, 61, 62, 63, 64, 65, 66, 67, 68.
References:
1.
Hasanah CI, Khan UA, Musalmah M, Razali SM. Reduced
red-cell folate in mania. J Affect Disord
46(2):95-9, 1997.
2.
Lipton M et al. Vitamins, megavitamin therapy and the
nervous system, in R Wurtman, J
3.
Wurtman, Eds. Nutrition and the Brain Vol. 33.
New York, Raven Press, 1979:183-264.
4.
Kallstrom B et al. Vitamin B12 and folate concentrations
in mental patients. Acta Psychiatr Scand
45;137-52, 1969.
5.
Hunter R et al. Serum B12 and folate concentration in
mental patients. Br J Psychiatry 113:1291-5,
1967.
6.
Botez MI et al. Relapsing neuropathy, cerebral atrophy
and folate deficiency. A close association. Appl
Neurophysiol 42(3):171-83, 1979.
7.
Coppen A et al. Depression and tetrahydrobiopterin: The
folate connection. J Affect Disord 16(2-3):103-7,
1989.
8.
McKeon P, Shelley R, O’Regan S, O’Broin J. Serum and red
cell folate and affective morbidity in lithium
prophylaxis. Acta Psychiatr Scand 83(3):199-201,
1991.
9.
Stern SL, Brandt JT, Harley KS, et al. Serum and red
cell folate concentrations in outpatients receiving
lithium carbonate. Int Clin Psychopharmacol
3(1):49-52, 1988.
10. Coppen A, Abou-Saleh MT. Plasma folate and affective
morbidity during long-term lithium therapy. Br J
Psychiatry 141:87-9, 1982.
11. Lee S, Chow CC, Shek CC, et al. Folate concentration
in Chinese psychiatric outpatients on long-term lithium
treatment. J Affect Disord 24(4):265-709, 1992.
12. Stern SL, Brandt JT, Harley KS, et al. Serum and red
cell folate concentrations in outpatients receiving
lithium carbonate. Int Clin Psychopharmacol
3(1):49-52, 1988.
13. Prakash R et al. A case report of megaloblastic
anemia secondary to lithium. Am J Psychiatry
138:849, 1981.
14. Lee S, Chow CC, Shek CC, et al. Folate concentration
in Chinese psychiatric outpatients on long-term lithium
treatment. J Affect Disord 24(4):265-70, 1992.
15. Coppen A, Abou-Saleh MT. Plasma folate and affective
morbidity during long-term lithium therapy. Br J
Psychiatry 141:87-9, 1982.
16. Coppen A, Chaudhry S, Swade C. Folid acid enhances
lithium prophylaxis. J Affect Disord 10(1):9-13,
1986.
17. Coppen A, Abou-Saleh MT. Plasma folate and affective
morbidity during long-term lithium therapy. Br J
Psychiatry 141:87-9. 1982.
18. Alpert JE, Fava M. Nutrition and depression: the
role of folate. Nutr Rev 55(5):145-9, 1997.
19. Ortega TM, Andres P, Lopez-Sobaler A, et al. [The
role of folates in the diverse biochemical processes
that control mental function]. Nutr Hosp
9(4):251-6, 1994.
20. Heseker H, Kubler W, Prudel V, Westenhoffer J.
Psychological disorders as early symptoms of a
mild-moderate vitamin deficiency. Ann N Y Acad Sci
669:352-7, 1992.
21. Shorvon SD, Carney MWP, Chanarin I, Reynolds EH. The
neuropsychiatry of megaloblastic anaemia. Br Med J
281:1036-42, 1980.
22. Howard JS. Folate deficiency in psychiatric
practice. Psychosomatics 16:112-15, 1975.
23. Alpert JE, Fava M. Nutrition and depression: the
role of folate. Nutr Rev 55(5):145-9, 1997.
24. Crellin R, Bottiglierei T, Reynolds EH. Folates and
psychiatric disorders. Clinical potential. Drugs
45(5):623-36, 1993.
25. Levitt AJ, Joffe RT. Folate, B12 and thyroid
function in depression. Biol Psychiatry
33(1):52-3, 1993.
26. Wolfersdorf M, Maier V, Froscher W, et al. [Folic
acid deficiency in patients hospitalized with
depression? A pilot study of clinical relevance].
Nervenarzt 64(4):269-72, 1993.
27. Bell IR et al. Complex vitamin patterns in geriatric
and young adult inpatients with major depression. J
Am Geriatr Soc 39(3):252-7, 1991.
28. Carney MW, Chary TK, Laundy M, et al. Red cell
folate concentrations in psychiatric patients. J
Affect Disord 19(3):207-13, 1990.
29. Godfrey PS, Toone BK, Carney MW, et al. Enhancement
of recovery from psychiatric illness by methylfolate.
Lancet 336:392-5, 1990.
30. Bell IR et al. Vitamin B12 and folate status in
acute geropsychiatric inpatients: Affective and
cognitive characteristics of a vitamin nondeficient
population. Biol Psychiatry 27(2):125-37, 1990.
31. Abou-Saleh MT, Coppen A. Serum and red blood cell
folate in depression. Acta Psychiatr Scand
80(1):78-82, 1989.
32. Knapp S, Irwin M. Plasma levels of
tetrahydrobiopterin and folate in major depression.
Biol Psychiatry 26(2):156-62, 1989.
33. Levitt AJ, Joffe RT. Folate, B12, and life course of
depressive illness. Biol Psychiatry 25(7):867-72,
1989.
34. Abou-Saleh MT, Coppen A. The biology of folate in
depression: Implications for nutritional hypotheses of
the psychoses. J Psychiatr Res 20(2):91-101,
1986.
35. Reynolds EH, Carney MWP, Toone BK. Methylation and
mood. Lancet ii: 196-8, 1984.
36. Merry J et al. Alcoholism, depression and plasma
folate. Letter. Br J Psychiatry 141:103-4, 1982.
37. Ghadirian AM, et al. Folic acid deficiency and
depression. Psychosomatics 21(11):926-9, 1980.
38. Trimble MR. Folic acid and mental symptoms in
children with epilepsy. J Neurol Neurosurg Psychiatry
43(11):1030-4, 1980.
39. Reynolds EH, Preece JM, Bailey J, Coppen A. Folate
deficiency in depressive illness. Br J Psychiatry
117:287-92, 1970.
40. Carney MEP. Serum folate values in 423 psychiatric
patients. Br Med J iv:512-16, 1967.
41. Young SN, Ghardirian AM. Folic acid and
psychopathology. Prog Neuropsychopharmacol Biol
Psychiatry 13(6):841-63, 1989.
42. Bottiglieri T et al. Enhancement of recovery from
psychiatric illness by methylfolate. Letter. Lancet
336:1579-80, 1990.
43. Reynolds EH, Carney MWP, Toone BK. Methylation and
mood. Lancet ii:196-8, 1984.
44. Coleman N. Laboratory assessment of folate status.
Clin Lab Med 12:775-96, 1981.
45. Lietha R, Zimmermann M. Neuropsychiatric disorders
associated with functional folate deficiency in the
presence of elevated serum and erythrocyte folate: a
preliminary report. J Nutr Med 4:441-7, 1994.
46. Fava M. Borus JS, Alpert JE, et al. Folate, vitamin
B12, and homosysteine in major depressive disorder.
Am J Psychiatry 154(3):426-8, 1997.
47. Arinami T, Yamada N, Yamakawa-Kobayashi K, et al.
Methylenetetrahydrofolate reductase variant and
schizophrenia/depression. Am J Med Genet
74(5):526-8, 1997.
48. Crellin R, Bottiglierei T, Reynolds EH. Folates and
psychiatric disorders. Clinical potential. Drugs
45(5):623-36, 1993.
49. Passeri M, Cucinotta D, Abate G, et al. Oral
5’-methyletrahydrofolic acid in senile organic mental
disorders with depression: results of a double-blind
multicenter study. Aging (Milano) 5(1):63-71,
1993.
50. Heseker H, Kubler W, Pudel V, Westenhoffer J.
Psychological disorders as early symptoms of a
mild-moderate vitamin deficiency. Ann N Y Acad Sci
669:352-7, 1992.
51. Procter A. Enhancement of recovery from psychiatric
illness by methylfolate. Br J Psychiatry
159:271-2, 1991.
52. Godfrey PS, Toone BK, Carney MW, et al. Enhancement
of recovery from psychiatric illness by methylfolate.
Lancet 336:392-5, 1990.
53. Coppen A. Folic acid enhances lithium prophylaxis.
J Affect Disord 10:9-13, 1986.
54. Botez MI, Young SN, Bachevalier J, Gauthier S.
Effect of folic acid and vitamin B12 deficiences on
5-hydroxyindoleacetic acid in human cerebrospinal fluid.
Ann Neurol 12(5):479-84, 1982.
55. Shorvon SD, Carney MWP, Chanarin I, Reynolds EH. The
neuropsychiatry of megaloblastic anaemia. Br Med
281:1036-42, 1980.
56. Botez MI, Botez T, Leveille J, et al.
Neuropsychological correlates of folic acid deficiency:
Facts and hypotheses, in MI Botez, EH Reynolds, Eds.
Folic Acid in Neurology, Psychiatry, and Internal
Medicine. New York, Raven Press, 1979:435-61.
57. Carney MWP. Psychiatric aspect of folate deficiency,
in MI Botez, EH Reynolds, Eds. Folic Acid in
Neurology, Psychiatry and Internal Medicine. New
York, Raven Press, 1979.
58. Botez MI, Cadotte M, Beaulieu R, et al. Neurologic
disorders responsive to folic acid therapy. J Can Med
Assoc 115-217-22. 1976.
59. Carney MWP, Sheffield BF. Associations of subnormal
serum folate and vitamin B12 and effects of replacement
therapy. J Nerv Ment Dis 150:404-12, 1970.
60. Ramchand CN, Ramchand R, Hemmings GP. RBC and serum
folate concentrations in neuroleptic-treated and
neuroleptic-free schizophrenic patients. J Nutr Med
3:303-9, 1992.
61. Carney MEP, Chary TKN, Laundy M, et al. Red cell
folate concentrations in psychiatric patients. J
Affect Dis 19:207-13, 1990.
62. Godfrey PS, Toone BK, Carney MW, et al. Enhancement
of recovery from psychiatric illness by methylfolate.
Lancet 336:392-5, 1990.
63. Carney MWP. Serum folate values in 423 psychiatric
patients. Br Med J 4:512-16, 1967.
64. Pfeiffer CC, Braverman ER. Folic acid and vitamin
B12 therapy for the low-histamine, high-copper biotype
of schizophrenia, in MI Botez, EN Reynolds, Eds.
Folic Acid in Neurology, Psychiatry, and Internal
Medicine. New York, Raven Press, 1979:483-7.
65. Procter A. Enhancement of recovery from psychiatric
illness by methylfolate. Br J Psychiatry
159:271-2, 1991.
66. Godfrey PS, Toone BK, Carney MW, et al. Enhancement
of recovery from psychiatric illness by methylfolate.
Lancet 336:392-5, 1990.
67. Donnelly S, Callaghan N. Subacute combined
degeneration of the spinal cord due to folate deficiency
in association with a psychotic illness. Ir Med J
83(2):73-4, 1990.
68. Carney MWP, Sheffield BF. Associations of subnormal
serum folate and vitamin B12 and effects of replacement
therapy. J Nerv Ment Dis 150:404-12, 1970.
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