Proper Name: Grape Seed Extract

Common Name: Grape Seed Extract

Evidence of Efficacy: statement to the effect of Grape seed extract deficiency or imbalance may play a role in the symptoms of mood disorders. Observational and experimental studies have shown a neuro-protective effect of grape seed^1,2,3,4.

References:

1. Bastianetto S, Quirion R.; Natural extracts as possible protective agents of brain aging.
Neurobiol Aging. 2002 Sep-Oct;23(5):891-97.
2. Bastianetto S, Zheng WH, Quirion R.; Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons.
Br J Pharmacol. 2000 Oct;131(4):711-20.
3. Zhuang H, Kim YS, Koehler RC, Dore S.; Potential mechanism by which resveratrol, a red wine constituent, protects neurons. Ann N Y Acad Sci. 2003 May;993:276-86; discussion 287-8.
4. Sun AY, Simonyi A, Sun GY.; The "French Paradox" and beyond: neuroprotective effects of polyphenols. Free Radic Biol Med. 2002 Feb 15;32(4):314-8.