Proper Name: Citrus Bioflavanoids

Common Name: Citrus Bioflavanoids

Evidence of Efficacy: statement to the effect of Citrus bioflavanoids deficiency or imbalance may play a role in the symptoms of mood disorders. Observational and experimental studies have shown a neuro-protective effect^1,2,3,4,5 of citrus bioflavanoids and improvement of the symptoms of premenstrual syndrome⁶.

References:

1. Datla KP, Christidou M, Widmer WW, Rooprai HK, Dexter DT.; Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease. Neuroreport. 2001 Dec 4; 12(17): 3871-5.
2. Schultke E, Kendall E, Kamencic H, Ghong Z, Griebel RW, Juurlink BH.; Quercetin promotes functional recovery following acute spinal cord injury. J Neurotrauma. 2003 Jun; 20(6): 583-91.
3. Fang F, Han YJ, Cui ZQ.; The protective effects of tea catechins on the injury of cerebral ischemia and reperfusion in rats. Zhongguo Zhong Yao Za Zhi. 2001 Nov; 26(11): 777-80.
4. Youdim KA, Dobbie MS, Kuhnle G, Proteggente AR, Abbott NJ, Rice-Evans C.; Interaction between flavonoids and the blood-brain barrier: in vitro studies. J Neurochem. 2003 Apr; 85(1): 180-92.
5. Kellis JT Jr, Vickery LE. Inhibition of human estrogen synthetase (aromatase) by flavones. Science 225:1032-4, 1984.
6. Amsellem M et al. Endotelon in the treatment of venolymphatic problems in premenstrual syndrome: multicenter study on 165 patients. Tempo Med 282, 1987.