Proper Name: Chromium

Common Name: Chromium

Evidence of Efficacy: statement to the effect of Chromium deficiency or imbalance plays a role in the symptoms of mood disorders. Observational and experimental studies have shown an association between chromium and depression^1,2,3,4.

References:

1. McLeod MN, Golden RN.; Chromium treatment of depression. Int J Neuropsychopharmacol. 2000 Dec;3(4):311-314.
2. McCarty MF.; Enhancing central and peripheral insulin activity as a strategy for the treatment of endogenous depression--an adjuvant role for chromium picolinate? Med Hypotheses. 1994 Oct;43(4):247-52.
3. Davidson JR, Abraham K, Connor KM, McLeod MN.; Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry. 2003 Feb 1;53(3):261-4.
4. McLeod MN, Gaynes BN, Golden RN.; Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psychiatry. 1999 Apr;60(4):237-40.